Untargeted Metabolomics Analysis of Serum Metabolites in Zucker Diabetic Fatty Rats
نویسندگان
چکیده
Zucker Diabtic Fatty rats is a common model used for the studies related to type 2 diabetes. Metabolomics, proven by previous studies, can be prediction of phenotype. This investigation held untargeted metabolomics analysis on serum metabolites Diabetic rats, intended gain insights in study pathology LCMS method (liquid chromatography coupled with mass spectrometry) an analytical chemistry technique separate and purify complex mixtures. After identifying using MS2 library spectrum matching, this Metabo Analyst compare fatty lean rats. Lastly, applying over representation analysis, we identified seven metabolic pathways that are important humans, which assists discovery therapeutic targets developments diabetes biomarkers.
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ژورنال
عنوان ژورنال: E3S web of conferences
سال: 2021
ISSN: ['2555-0403', '2267-1242']
DOI: https://doi.org/10.1051/e3sconf/202123302017